“TSM” (often shorthand for Tesamorelin) and “Tesa” refer to a synthetic, 44-amino-acid analog of Growth Hormone-Releasing Hormone (GHRH). It is primarily studied and prescribed to stimulate the pituitary gland into releasing the body’s own growth hormone, focusing on visceral (belly) fat reduction.
Core Mechanisms & Benefits
- Visceral Fat Reduction: Its primary clinical use is reducing excess deep abdominal fat.
- GHRH Analog: Tesamorelin mimics natural GHRH but is structurally modified to resist enzymatic breakdown, allowing for a longer half-life in the body.
- Metabolic Support: It increases IGF-1 (Insulin-like Growth Factor 1) levels, which research suggests may improve lipid profiles and overall body composition.
Clinical Context
- FDA Indication: Under the brand name Egrifta, it is officially FDA-approved to treat HIV-associated lipodystrophy (abnormal fat distribution).
- Off-Label Use: In functional medicine and anti-aging clinics, it is sometimes utilized off-label for non-HIV patients looking to reduce stubborn abdominal fat and improve metabolic markers.
Common Peptide Blends
Researchers and compounding pharmacies often combine Tesamorelin with other peptides to create a synergistic metabolic effect:
- Tesa/Ipamorelin (Tesa/Ipa): Ipamorelin is a Growth Hormone Secretagogue (GHRP) that works with Tesamorelin to enhance natural growth hormone pulsatility without spikes in cortisol or prolactin.
- Tesa/Ipa/MOTS-c: This combination adds MOTS-c (a mitochondrial peptide) to improve cellular energy, insulin sensitivity, and nutrient processing alongside fat loss.
Sourcing & Providers
Tesamorelin is a prescription-only medication. However, as a standalone compound or in blends, it is widely sold by chemical and research supply companies. If you are exploring clinical use or sourcing, you can check specific formulations and research availability directly through providers like Puratek Peptides, Ion Peptide, Liberty Peptides, and Alpha Omega Peptide.
| TSM | 5mg*10vials, 10mg*10vials |
|---|
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